Resistance vs resilience to Alzheimer disease
نویسندگان
چکیده
منابع مشابه
Cognitive profiles in dementia: Alzheimer disease vs healthy brain aging.
OBJECTIVE To re-examine proposed models of cognitive test performance that concluded separate factor structures were required for people with Alzheimer disease (AD) and older adults without dementia. METHODS Five models of cognitive test performance were compared using multistep confirmatory factor analysis in 115 individuals with autopsy-confirmed AD and 191 research participants without cli...
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A growing body of clinical and epidemiological research suggests that two of the most common diseases of aging, type 2 diabetes (T2DM) and Alzheimer disease (AD), are linked. The nature of the association is not known, but this observation has led to the notion that drugs developed for the treatment of T2DM may be beneficial in modifying the pathophysiology of AD and maintaining cognitive funct...
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OBJECTIVE To answer the question of whether onset of insulin resistance (IR) early in life enhances the risk of developing dementia and Alzheimer disease (AD), serum levels of 2 molecules that are likely associated with development of AD, the amyloid β-protein 42 (Aβ42) and presenilin 1 (PSEN1), were estimated in 101 preschoolers and 309 adolescents of various BMI. METHODS Participants (215 b...
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Alzheimer disease (AD) is the most common cause of dementia in North America. Despite 30+ years of intensive research, gaps remain in our understanding of AD pathogenesis and approaches to treatment. However, the recent rapid shift to a paradigm that focuses on the roles of metabolic dysfunction and insulin and insulin-like growth factor (IGF) resistance as causal agents of cognitive impairment...
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Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common form of dementia. Almost 47 million people suffer from dementia worldwide. AD accounts for approximately 60%–80% of all dementia cases. Three major pathologies characterize the disease: senile plaques, neurofibrillary tangles and inflammation. We review the literature on events contributing to the inflammat...
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ژورنال
عنوان ژورنال: Neurology
سال: 2018
ISSN: 0028-3878,1526-632X
DOI: 10.1212/wnl.0000000000005303